Paragonix BAROguard®

The Next Generation of Lung Preservation
The Paragonix BAROguard® System unveils a new degree of standardization in preservation technology with the introduction of an automated pressure regulation system.
Doctor holding human heart
The vanguard of Paragonix active control systems
Automated management of lung airway pressure
Uphold critical variables to clinical recommendations1
The Forefront of Lung Transportation
Building on the legacy of its predecessors, the BAROguard system is the first commercially available hypothermic preservation system that is equipped to automatically calibrate the airway pressure of donor lungs during transportation. This leading-edge device incorporates a never-before-seen pressure system that actively maintains the donor lungs at an appropriate and consistent level of inflation pressure, regardless of external, fluctuating variables such as ambient pressures, ambient temperatures, or surgical recovery techniques.
Caution: Federal (US) law restricts this device to sale by or on the order of a licensed health care practitioner. Please refer to Instructions for Use for full prescribing information. Cleared indication is for 8 hour use. Patents issued and pending. See legal page for more information.
Active Pressure Control
According to a 2020 consensus statement on donor heart and lung procurement, The International Society for Heart and Lung Transplantation recommends that explanted donor lungs should be inflated at a static pressure of 12-15 cm of water pressure (cm H20). Traditionally, surgical recovery techniques are unable to monitor or control inflation, potentially exposing the lungs to suboptimal pressures outside the clinically recommended range. It has been shown that both over- and underinflation may risk damage to the donor lungs during transport.

The BAROguard system is the first – and only – preservation device capable of adjusting the inflation pressure to the clinically recommended range, regardless of ambient pressures. The device actively monitors for fluctuations in pressure, then automatically adjusts to an appropriate level and relays real-time metrics directly to the Paragonix app.
Technological Advantage of Advanced Organ Preservation
Traditional Ice Storage
  • Uses commercial-grade coolers unregulated by the FDA
  • Exposes the the donor lung(s) to an unmonitored  environment of 0°C ice
  • Lung tissue is exposed to uneven cooling, potentially risking freezing injury
  • Unpredictable temperature reductions within the ice cooler are not monitored during transport
  • Unmonitored pressure fluctuations risk trauma associated with over- or under-inflation of donor lungs
Paragonix BAROguard
  • An FDA-cleared preservation device intended to actively protect and monitor donor lung(s) in transit
  • Validated to maintain a consistent thermal environment
  • Utilizes SherpaCool® phase-change technology to prevent exposure to excessive temperature reduction
  • Automates management of donor lungs’ airway pressure throughout the journey for unprecedented control
  • Records temperature, pressure, location, and case status in real-time
Merging industry-leading preservation technology with an integrated pressure control system
Key Features
Rigid Outer Shell
Protective polystyrene material ensures internal environment will maintain temperature
SherpaCool Technology
Proprietary phase-change cooling formula that maintains optimal temperature conditions without the use of 0°C ice
Triple Bag System
Industry-standard, best-in-class bagging system
Active Airway Pressure Control
Automated system actively maintains pressure at ISHLT recommended range of 12-15 cm H2O relative to environment
Temperature Probe
Embedded probe continuously monitors and records the internal and ambient temperatures
Monitor and Data Transmission
Simple Bluetooth® pairing allows the system to transmit full data reports to as many users as necessary
Advancing the Science of Preservation
The GUARDIAN-Lung clinical registry is a post-market, observational registry of lung transplant recipient patients whose donor lung was preserved and transported using the Paragonix LUNGguard® Donor Lung Preservation System, or the Paragonix BAROguard® Donor Lung Preservation System. Our panel of clinical investigators analyze the post-transplant outcomes of Paragonix advanced lung preservation technologies in comparison to traditional ice storage.

The data is being collected retrospectively from medical records of patients already transplanted before the initiation of the registry and any new patients who meet the eligibility criteria.
Learn More
Follow your transplant’s journey from beginning to end
The Paragonix App and Web Portal allows transplant teams to coordinate case logistics in a centralized, secure platform designed specifically for use in a real-world setting. And, if greater logistical support is needed, you can rely on our network of experienced personnel to expand your surgical coverage.
Learn More About Our Digital Services
Or, Learn More About Our Organ Procurement Services
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Important Safety Information

Indications for Use
The Paragonix BAROguard® (BAROguard) is intended to be used for the static hypothermic preservation of lungs during transportation and eventual transplantation into a recipient using cold storage solutions indicated for use with the lungs. The intended organ storage time for BAROguard® is up to 8 hours.
Donor lungs exceeding clinically accepted static hypothermic preservation times should be evaluated by the transplant surgeon to determine transplantability in accordance with accepted clinical guidelines and in the best medical interest of the intended recipient.

Note: Partial lungs can be transported via BAROguard by packaging lungs per institutional protocol and UNOS guidelines.
Request more information about our contributions to advancing donor organ transplantation.
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