Paragonix LIVERguard®

Donor Liver Preservation System
In the mission-critical world of transplantation, where there is no margin for error, Paragonix delivers the most advanced technologies to support transplant teams around the world every day.
Doctor holding human heart
Prevent physical and thermal trauma
Move on from ice and unpredictable results
A repeatable and measurable process
Addressing the Risks of Cold Ischemia Time
Cold ischemia time refers to the period of time during which a donor liver is cooled to maintain its viability until it can be transplanted into the recipient. The length of cold ischemia time may vary greatly, although prolonged cold ischemia time is traditionally associated with greater risk of complications after the transplant procedure. Research has linked longer cold ischemia times with poor outcomes, such as longer post-transplant hospital stays and a higher rate of primary graft nonfunction.1,2

Traditionally, donor livers destined for transplantation were placed into commercial-grade coolers filled with ice to transport it to the recipient. This method presents a multitude of uncontrolled variables that can also impact the function of the liver post-transplant. Clinical evidence has shown that the use of ice can expose donor organs to freezing temperatures, leading to irreversible cellular damage.3

The Paragonix LIVERguard is an Advanced Organ Preservation device specifically designed to standardize the variables of donor liver preservation, providing physicians with stable cooling technology driven by real-time data monitoring.
Caution: Federal (US) law restricts this device to sale by or in the order of a licensed health care practitioner. Please refer to Instructions for Use for full prescribing information. Cleared indication is for 15-hour use. Patents issued and pending. See Indications For Use for more information.
Technological Advantage of Advanced Organ Preservation
Traditional Ice Storage
  • Uses commercial-grade coolers unregulated by the FDA
  • Exposes the the donor liver to an unmonitored environment of 0°C ice
  • Liver tissue is exposed to uneven cooling, potentially risking freezing injury
  • Unpredictable temperature reductions within the ice cooler are not monitored during transport
Paragonix LIVERguard
  • An FDA-cleared and CE-marked preservation device intended to protect the donor liver in transit
  • Validated to maintain a consistent thermal environment
  • Utilizes SherpaCool® phase-change technology to prevent exposure to excessive temperature reduction
  • Records temperature, location, and case status in real-time
Offering a controlled approach designed for ease-of-use in a clinical setting.
Key Features
Rigid Outer Shell
Protective polystyrene material ensures internal environment will maintain temperature
SherpaCool Technology
Proprietary phase-change cooling formula that maintains optimal temperature conditions without the use of 0°C ice
Triple Bag System
Industry-standard, best-in-class bagging system
Temperature Probe
Embedded probe continuously monitors and records the internal and ambient temperatures
Monitor and Data Transmission
Simple Bluetooth® pairing allows the system to transmit full data reports to as many users as necessary
Multi-Center Clinical Research
To measure the clinical impact of advanced liver preservation, Paragonix leads the novel GUARDIAN-Liver Clinical Registry. Our panel of clinical investigators analyze the post-transplant outcomes of the LIVERguard in comparison to traditional ice storage.

The GUARDIAN-Liver study is a post-market, observational registry of adult liver transplant recipient patients whose donor liver was preserved and transported using the Paragonix LIVERguard® Donor Liver Preservation System. The data is being collected retrospectively from medical records of patients already transplanted before the initiation of the registry and any new patients who meet the eligibility criteria.
Learn more
Follow your transplant’s journey from beginning to end
The Paragonix App and Web Portal allows transplant teams to coordinate case logistics in a centralized, secure platform designed specifically for use in a real-world setting. And, if greater logistical support is needed, you can rely on our network of experienced personnel to expand your surgical coverage.
Learn More About Our Digital Services
Or, Learn More About Our Organ Procurement Services
Paragonix App

Important Safety Information

Indications for Use
The Paragonix LIVERguard® Donor Liver Transport System is intended to be used for the static hypothermic preservation of livers during transportation and eventual transplantation into a recipient using cold storage solutions indicated for use with donor livers.The intended organ storage time for the LIVERguard® system is up to 15 hours.
Donor livers exceeding clinically accepted static hypothermic preservation times should be evaluated by the transplant surgeon to determine transplantability in accordance with accepted clinical guidelines and in the best medical interest of the intended recipient.

Note: A partial liver can be transported via the LIVERguard® System by packaging liver per institutional protocol and UNOS guidelines.
Request more information about our contributions to advancing donor organ transplantation.
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