Paragonix LUNGguard®

Donor Lung Preservation System
One of the leading FDA-cleared and CE-marked preservation devices for lung transportation, the Paragonix LUNGguard® offers a sterile, controlled environment that protects donor lungs from both physical and thermal damage.
Doctor holding human heart
SherpaPak
Over 500
Donor lungs preserved
Over 80
Transplant centers
Over 35
Clinical publications
Advancing Lung Preservation
The endothelium of the lung is an extremely vulnerable tissue. Outside of the body, cells once safeguarded by protective homeostatic conditions are suddenly exposed to a highly variable environment, which can cause harm to such an important layer of tissue. Traditionally, donor lungs destined for transplantation were placed into commercial-grade coolers filled with ice to transport it to the recipient. This method presents a multitude of uncontrolled variables that can also impact the post-transplant function of the lung. Clinical evidence has shown that the use of ice can expose the donor lung to freezing temperatures, leading to irreversible cellular damage.1

The Paragonix LUNGguard is an Advanced Organ Preservation device specifically designed to standardize the variables of donor lung preservation, providing physicians with stable cooling technology driven by real-time data monitoring.
Caution: Federal (US) law restricts this device to sale by or in the order of a licensed health care practitioner. Please refer to Instructions for Use for full prescribing information. Cleared indication is for 8-hour use. Patents issued and pending. See Indications For Use for more information.
Technological Advantage of Advanced Organ Preservation
Traditional Ice Storage
  • Uses commercial-grade coolers unregulated by the FDA
  • Exposes the the donor lung(s) to an unmonitored  environment of 0°C ice
  • Lung tissue is exposed to uneven cooling, potentially risking freezing injury
  • Unpredictable temperature reductions within the ice cooler are not monitored during transport
Paragonix LUNGguard
  • An FDA-cleared and CE-marked preservation device intended to protect the donor lung(s) in transit
  • Validated to maintain a consistent thermal environment
  • Utilizes SherpaCool® phase-change technology to prevent exposure to excessive temperature reduction
  • Records temperature, location, and case status in real-time
Move on from Ice and Unpredictable Results
Key Features
1
Rigid Outer Shell
Protective polystyrene material ensures internal environment will maintain temperature over 40 hours
2
SherpaCool Technology
Proprietary phase-change cooling formula that maintains optimal temperature conditions without the use of 0°C ice
3
Triple Bag System
Industry-standard, best-in-class bagging system
4
Temperature Probe
Embedded probe continuously monitors and records the internal and ambient temperatures
5
Monitor and Data Transmission
Simple Bluetooth® pairing allows the system to transmit full data reports to as many users as necessary
Advancing the Science of Preservation
To measure the clinical impact of advanced lung preservation, Paragonix leads the novel GUARDIAN-Lung Clinical Registry. Our panel of clinical investigators analyze the post-transplant outcomes of the LUNGguard in comparison to traditional ice storage.

The GUARDIAN-Lung study is a post-market, observational registry of  lung transplant recipient patients whose donor lung was preserved and transported using the Paragonix LUNGguard® Donor Lung Preservation System. The data is being collected retrospectively from medical records of patients already transplanted before the initiation of the registry and any new patients who meet the eligibility criteria.
Learn More
Follow your transplant’s journey from beginning to end
The Paragonix App and Web Portal allows transplant teams to coordinate case logistics in a centralized, secure platform designed specifically for use in a real-world setting. And, if greater logistical support is needed, you can rely on our network of experienced personnel to expand your surgical coverage.
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Or, Learn More About Our Organ Procurement Services
Paragonix App

Important Safety Information

Indications for Use
The Paragonix LUNGguard® (LUNGguard®) is intended to be used for the static hypothermic preservation of lungs during transportation and eventual transplantation into a recipient using cold storage solutions indicated for use with the lungs.
The intended organ storage time for LUNGguard® is up to 8 hours.
Donor lungs exceeding clinically accepted static hypothermic preservation times should be evaluated by the transplant surgeon to determine transplantability in accordance with accepted clinical guidelines and in the best medical interest of the intended recipient.

Note: Partial lungs can be transported via LUNGguard® by packaging lungs per institutional protocol and UNOS guidelines.
References
Request more information about our contributions to advancing donor organ transplantation.
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